A second RDBPC clinical study confirmed that BrainPhyt™ may enhances memory, attention, and stress response in healthy adults with age-associated memory impairment

A new clinical study recently published in Frontiers in Aging has revealed promising results: BrainPhyt™, a patented extract derived from the microalga Phaeodactylum tricornutum, may improves memory, attention, and overall cognitive performance while reducing perceived stress in healthy older adults. These findings reinforce the potential of microalgae-based ingredients as natural allies for preserving brain function as we age.

Produced sustainably in the South of France using our patented hydro-biomimetic technology, BrainPhyt features a full-spectrum composition naturally rich in fucoxanthin, omega-3 fatty acids, and phycoprostanes. Fucoxanthin is a powerful antioxidant capable of crossing the blood-brain barrier, which explains its beneficial effects on stress regulation and cognitive health.It contains the highest authorized daily dose of fucoxanthin on the U.S. market and holds NDI (New Dietary Ingredient) status. This makes it a premium and clinically supported solution to meet the growing demand for natural cognitive health ingredients.

A fast growing consumer need

As the global population ages, cognitive health is becoming a top priority for many consumers. By 2050, adults aged 60 and older are expected to account for more than 20% of the world’s population—over 2 billion individuals¹. Their main concerns? Slowing the natural decline in memory, focus and mental clarity, and maintaining autonomy and quality of life.

This is especially important because cognitive decline is not just about memory: it often starts silently, impacting attention, processing speed and emotional balance, and progressively affecting day-to-day life. In this context, consumers are increasingly turning to natural, clinically proven supplements to support their brain function and emotional well-being.

BrainPhyt was developed precisely to answer this growing demand—by offering a holistic, plant-based approach to healthy brain ageing.

Clinical study highlights: improved cognition and reduced stress

To evaluate the efficacy of BrainPhyt, a 6-month randomized, double-blind, placebo-controlled trial was conducted by Atlantia Clinical Trials in Cork, Ireland. The study enrolled 66 healthy adults aged 55–75 with age-associated memory impairment, who received either a daily dose of BrainPhyt (containing 4.4 mg of fucoxanthin) or a placebo.

Cognitive function was assessed using the COMPASS computerized test system. In addition to questionnaires on mood, sleep and perceived stress (PSS), blood samples were analyzed to monitor biomarkers of inflammation and stress, including C-reactive protein (CRP).

The results were compelling:

• 53% improvement in episodic memory vs. placebo
• 2.5× increase in attention and vigilance, reflecting improved executive function
• −45% reduction in CRP (C-Reactive Protein), “resetting the clock” by up to 10 years in terms of in terms of brain function profile.
• Significant decrease in perceived stress, helping to break the stress-cognition cycle

These outcomes highlight BrainPhyt’s dual-action effect on cognitive and emotional health, addressing both memory decline and stress—a major contributor to accelerated brain ageing.

Backed by multiple clinical studies

This new study builds on the promising results of a previous 12-week trial conducted by Texas A&M University, which also showed significant improvements in memory, attention, and executive function.

Together, these two clinical trials confirm that BrainPhyt acts through a multidimensional mechanism of action, delivering consistent benefits across different country and study designs.

A next-generation ingredient for cognitive well-being

With a unique composition, BrainPhyt offers a powerful and natural way to support brain health, with demonstrated benefits on memory, attention, mood, and stress.

Its efficacy at a low daily dose (220mg for the liquid grade or 750mg for the CWD powder grade, each delivering 4.4mg fucoxanthin per day), its plant-based and sustainable origin, and its robust clinical backing make it a compelling solution for formulators and brands looking to meet the growing expectations of ageing consumers in a clean, innovative and effective way.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sources

¹NBJ December 2022 Trends Issues & New Hope Network NEXT Data & Insights survey